Apml online dating
Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi - 110 029 India Source of Support: None, Conflict of Interest: None The use of all trans-retinoic acid (ATRA) and combination chemotherapy has made acute promyelocytic leukemia (APL) a potentially curable leukemia.
Three years later, she developed acute myeloid leukemia (AML), M2 subtype without any evidence of relapse of the APL clone.
The median latent period from achievement of CR to diagnosis of t-MDS/AML was 34 months (range 25-40 months).
All patients presented with the chromosome abnormalities, mostly deletions or loss of the long arm of chromosome 5 and/or 7, or balanced translocations involving the 21q22 band.
In a retrospective analysis over a 12 year study period, secondary clonal cytogenetic aberrations (CCA) following therapy for APL (ATRA with chemotherapy) was seen in 12 out of 123 patients (9.8%), who were in CR.
A 32-year-old housewife presented with 1 month history of fever, bleeding per vaginum, and pancytopenia.This was followed by consolidation and maintenance which was completed by April 2009.The patient remained in CR until December 2010, when she presented with fever, weakness, and pancytopenia.She opted for supportive care and finally succumbed to her illness.The patient described in this report was diagnosed with the acute promyelocytic leukemia (APL) according to the typical morphology and PML-RARA rearrangements.
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Seven patients with secondary CCA are alive without any evidence of leukemia.